HMGCL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046951Biological processketone body biosynthetic process
GO_0007005Biological processmitochondrion organization
GO_0006629Biological processlipid metabolic process
GO_0006552Biological processL-leucine catabolic process
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0030145Molecular functionmanganese ion binding
GO_0004419Molecular functionhydroxymethylglutaryl-CoA lyase activity
GO_0046872Molecular functionmetal ion binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameHMGCL
Protein nameHydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
Mutant 3-hydroxymethyl-3-methylglutaryl-CoA lyase, transcript variant 1
Alternative protein HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
SynonymshCG_37683
DescriptionFUNCTION: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. .

FUNCTION: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. .

FUNCTION: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. .

AccessionsENST00000374490.8 [P35914-1]
P35914
ENST00000436439.6 [P35914-2]
L8EC54
ENST00000235958.4
H0Y2L7
B1AK13
G8FGB4