HECTD3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HECTD3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HECTD3 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameHECTD3
Protein nameHECT domain containing 3 (cDNA FLJ31983 fis, clone NT2RP7008557, highly similar to Probable E3 ubiquitin-protein ligase HECTD3)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
SynonymshCG_1815097
DescriptionFUNCTION: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). .

AccessionsA1A4G1
ENST00000372172.5 [Q5T447-1]
ENST00000372168.7 [Q5T447-2]
Q5T447