I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 29% ± 10% | |
| ciliated cell | 3 studies | 25% ± 0% | |
| dendritic cell | 3 studies | 25% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 29% ± 10% | |
| ciliated cell | 3 studies | 25% ± 0% | |
| dendritic cell | 3 studies | 25% ± 5% |
Insufficient scRNA-seq data for expression of HDGFL2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 0% | 0 | 0 / 0 | 100% | 31.58 | 183 / 183 |
| eye | 0% | 0 | 0 / 0 | 100% | 57.63 | 80 / 80 |
| liver | 0% | 0 | 0 / 0 | 100% | 39.59 | 406 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 83.48 | 29 / 29 |
| pancreas | 0% | 0 | 0 / 0 | 100% | 48.03 | 178 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 62.63 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 69.15 | 1 / 1 |
| thymus | 0% | 0 | 0 / 0 | 100% | 64.48 | 604 / 605 |
| skin | 0% | 0 | 0 / 0 | 100% | 61.02 | 471 / 472 |
| uterus | 0% | 0 | 0 / 0 | 100% | 70.72 | 458 / 459 |
| ovary | 0% | 0 | 0 / 0 | 100% | 38.14 | 429 / 430 |
| brain | 0% | 0 | 0 / 0 | 100% | 78.49 | 703 / 705 |
| adrenal gland | 0% | 0 | 0 / 0 | 100% | 53.99 | 229 / 230 |
| prostate | 0% | 0 | 0 / 0 | 99% | 52.49 | 498 / 502 |
| kidney | 0% | 0 | 0 / 0 | 99% | 35.88 | 893 / 901 |
| stomach | 0% | 0 | 0 / 0 | 99% | 35.00 | 283 / 286 |
| intestine | 0% | 0 | 0 / 0 | 99% | 38.91 | 521 / 527 |
| bladder | 0% | 0 | 0 / 0 | 98% | 56.55 | 496 / 504 |
| breast | 0% | 0 | 0 / 0 | 98% | 47.20 | 1100 / 1118 |
| lung | 0% | 0 | 0 / 0 | 98% | 37.71 | 1134 / 1155 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006310 | Biological process | DNA recombination |
| GO_0006281 | Biological process | DNA repair |
| GO_0043403 | Biological process | skeletal muscle tissue regeneration |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0007517 | Biological process | muscle organ development |
| GO_0140861 | Biological process | DNA repair-dependent chromatin remodeling |
| GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
| GO_0042692 | Biological process | muscle cell differentiation |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0035064 | Molecular function | methylated histone binding |
| GO_0061628 | Molecular function | H3K27me3 modified histone binding |
| GO_0062072 | Molecular function | H3K9me3 modified histone binding |
| GO_0140566 | Molecular function | histone reader activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HDGFL2 |
| Protein name | HDGF like 2 Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) |
| Synonyms | HDGFRP2 HRP2 UNQ785/PRO1604 HDGF2 |
| Description | FUNCTION: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) . Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters . Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs . Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 . Involved in cellular growth control, through the regulation of cyclin D1 expression . . |
| Accessions | ENST00000614903.1 K7ERA4 ENST00000589486.5 A0A087WZ99 ENST00000616600.5 [Q7Z4V5-1] K7EJP7 A0A087WT54 ENST00000587016.5 ENST00000592691.1 ENST00000619255.1 K7EPS6 ENST00000601353.5 ENST00000592417.2 A0A087WX58 ENST00000621835.4 [Q7Z4V5-2] ENST00000615225.1 Q7Z4V5 M0R0J3 K7EQ06 |
