I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 31% ± 7% | |
| ciliated cell | 3 studies | 24% ± 5% | |
| macrophage | 3 studies | 16% ± 1% | |
| dendritic cell | 3 studies | 28% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 31% ± 7% | |
| ciliated cell | 3 studies | 24% ± 5% | |
| macrophage | 3 studies | 16% ± 1% | |
| dendritic cell | 3 studies | 28% ± 3% |
Insufficient scRNA-seq data for expression of HCCS at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1152.12 | 1445 / 1445 | 100% | 36.87 | 183 / 183 |
| intestine | 100% | 1302.26 | 966 / 966 | 100% | 49.84 | 527 / 527 |
| stomach | 100% | 841.97 | 359 / 359 | 100% | 48.40 | 286 / 286 |
| breast | 100% | 869.90 | 459 / 459 | 100% | 37.95 | 1116 / 1118 |
| bladder | 100% | 904.43 | 21 / 21 | 100% | 40.43 | 502 / 504 |
| skin | 100% | 1310.15 | 1809 / 1809 | 100% | 35.87 | 470 / 472 |
| liver | 100% | 610.36 | 225 / 226 | 100% | 25.65 | 406 / 406 |
| ovary | 100% | 594.56 | 180 / 180 | 100% | 30.81 | 428 / 430 |
| uterus | 99% | 603.58 | 169 / 170 | 100% | 44.75 | 459 / 459 |
| thymus | 100% | 752.11 | 652 / 653 | 100% | 26.48 | 602 / 605 |
| kidney | 100% | 1096.85 | 89 / 89 | 99% | 34.16 | 895 / 901 |
| lung | 99% | 830.49 | 574 / 578 | 100% | 36.46 | 1153 / 1155 |
| prostate | 100% | 677.14 | 244 / 245 | 99% | 25.22 | 499 / 502 |
| adrenal gland | 100% | 1114.43 | 258 / 258 | 99% | 34.15 | 227 / 230 |
| brain | 97% | 740.10 | 2565 / 2642 | 100% | 24.42 | 702 / 705 |
| pancreas | 94% | 359.06 | 307 / 328 | 99% | 32.29 | 176 / 178 |
| adipose | 100% | 924.05 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 43.10 | 29 / 29 |
| muscle | 100% | 2207.78 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1050.87 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 46.63 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 18.62 | 1 / 1 |
| blood vessel | 100% | 791.99 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 23.86 | 79 / 80 |
| heart | 97% | 1708.89 | 836 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 863.18 | 884 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018063 | Biological process | cytochrome c-heme linkage |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0020037 | Molecular function | heme binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004408 | Molecular function | holocytochrome-c synthase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | HCCS |
| Protein name | Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase) |
| Synonyms | CCHL |
| Description | FUNCTION: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. . |
| Accessions | ENST00000380762.5 P53701 ENST00000380763.7 ENST00000321143.8 |
