HAVCR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HAVCR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HAVCR1 at tissue level.

III. Associated gene sets

GO_0033005Biological processpositive regulation of mast cell activation
GO_0046718Biological processsymbiont entry into host cell
GO_0006911Biological processphagocytosis, engulfment
GO_0031514Cellular componentmotile cilium
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0001786Molecular functionphosphatidylserine binding
GO_0005515Molecular functionprotein binding
GO_0001618Molecular functionvirus receptor activity

IV. Literature review

[source]
Gene nameHAVCR1
Protein nameHepatitis A virus cellular receptor 1c
Hepatitis A virus cellular receptor 1b
Hepatitis A virus cellular receptor 1a
Hepatitis A virus cellular receptor 1
Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365)
SynonymsTIM1
TIMD1
KIM1
DescriptionFUNCTION: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses . Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease . Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair . .; FUNCTION: (Microbial infection) Acts as a receptor for Hepatitis A virus. .; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane . Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP . .; FUNCTION: (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane . TIM1 and Dengue virus are co-internalized during virus entry . .; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. .; FUNCTION: (Microbial infection) Plays a positive role in Chikungunya virus cell entry. .

AccessionsE9PFX0
ENST00000522693.5
A0A8V8TMP5
ENST00000339252.8
ENST00000698790.1
F1CME6
F1CME7
ENST00000699093.1
Q96D42
ENST00000523175.6
F1CME8
A0A8V8TPG0