HASPIN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HASPIN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HASPIN at tissue level.

III. Associated gene sets

GO_0071459Biological processprotein localization to chromosome, centromeric region
GO_0035556Biological processintracellular signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0007064Biological processmitotic sister chromatid cohesion
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0000278Biological processmitotic cell cycle
GO_0006338Biological processchromatin remodeling
GO_0005813Cellular componentcentrosome
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005819Cellular componentspindle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0072354Molecular functionhistone H3T3 kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameHASPIN
Protein nameSerine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymsGSG2
DescriptionFUNCTION: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. .

AccessionsENST00000325418.5 [Q8TF76-1]
A0PJ70
Q8TF76