HACL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006625Biological processprotein targeting to peroxisome
GO_1903512Biological processphytanic acid metabolic process
GO_0097089Biological processmethyl-branched fatty acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0001561Biological processfatty acid alpha-oxidation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0106376Molecular function2-hydroxyphytanoyl-CoA lyase activity
GO_0030976Molecular functionthiamine pyrophosphate binding
GO_0016830Molecular functioncarbon-carbon lyase activity
GO_0005524Molecular functionATP binding
GO_0106359Molecular function2-hydroxyacyl-CoA lyase activity
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameHACL1
Protein name2-hydroxyacyl-CoA lyase 1 (Phytanoyl-CoA 2-hydroxylase 2, isoform CRA_c) (cDNA FLJ32415 fis, clone SKMUS2000724, highly similar to 2-hydroxyphytanoyl-CoA lyase)
2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2)
2-hydroxyacyl-CoA lyase 1 (HACL1 protein)
2-hydroxyacyl-CoA lyase 1
SynonymsPHYH2
HPCL2
HPCL
HSPC279
hCG_1811148
DescriptionFUNCTION: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner . Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids . Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). .

AccessionsQ9UJ83
ENST00000456194.6 [Q9UJ83-2]
C9J306
C9JJM7
ENST00000422591.5
ENST00000414979.1
ENST00000421993.5
ENST00000435217.6
Q7Z773
ENST00000383779.8
B3KPX4
F8WCH9
ENST00000628377.2
ENST00000321169.10 [Q9UJ83-1]
ENST00000451445.6 [Q9UJ83-3]
ENST00000457447.6 [Q9UJ83-4]