H6PD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031667Biological processresponse to nutrient levels
GO_2000064Biological processregulation of cortisol biosynthetic process
GO_0006006Biological processglucose metabolic process
GO_0097305Biological processresponse to alcohol
GO_0009051Biological processpentose-phosphate shunt, oxidative branch
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0004345Molecular functionglucose-6-phosphate dehydrogenase activity
GO_0017057Molecular function6-phosphogluconolactonase activity
GO_0047935Molecular functionglucose 1-dehydrogenase (NADP+) activity
GO_0050661Molecular functionNADP binding
GO_0030246Molecular functioncarbohydrate binding
GO_0047936Molecular functionglucose 1-dehydrogenase [NAD(P)+] activity
GO_0047934Molecular functionglucose 1-dehydrogenase (NAD+) activity

IV. Literature review

[source]
Gene nameH6PD
Protein nameGDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]
SynonymsGDH
DescriptionFUNCTION: Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway . In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum . By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity . .

AccessionsENST00000377403.7 [O95479-1]
ENST00000602477.1 [O95479-2]
O95479