H3-5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H3-5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H3-5 at tissue level.

III. Associated gene sets

GO_0030307Biological processpositive regulation of cell growth
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031492Molecular functionnucleosomal DNA binding
GO_0005515Molecular functionprotein binding
GO_0030527Molecular functionstructural constituent of chromatin

IV. Literature review

[source]
Gene nameH3-5
Protein nameHistone H3.3C (Histone H3.5)
SynonymsH3F3C
DescriptionFUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. .

AccessionsENST00000340398.5
Q6NXT2