H2BC12L report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2BC12L at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2BC12L at tissue level.

III. Associated gene sets

GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227Biological processinnate immune response in mucosa
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0021762Biological processsubstantia nigra development
GO_0019731Biological processantibacterial humoral response
GO_0005615Cellular componentextracellular space
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0030527Molecular functionstructural constituent of chromatin

IV. Literature review

[source]
Gene nameH2BC12L
Protein nameHistone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s)
SynonymsH2BFS
H2BS1
DescriptionFUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

AccessionsP57053
ENST00000599962.2