H2AL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2AL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2AL3 at tissue level.

III. Associated gene sets

GO_0031507Biological processheterochromatin formation
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031492Molecular functionnucleosomal DNA binding
GO_0030527Molecular functionstructural constituent of chromatin

IV. Literature review

[source]
Gene nameH2AL3
Protein nameHistone H2A-like 3 (H2A.L.3)
SynonymsH2AL1RP
DescriptionFUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .

AccessionsENST00000448797.3
A0A3B3IU63