H2AB1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2AB1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2AB1 at tissue level.

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_0000791Cellular componenteuchromatin
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031492Molecular functionnucleosomal DNA binding

IV. Literature review

[source]
Gene nameH2AB1
Protein nameHistone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd)
SynonymsH2AFB1
DescriptionFUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability . Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo . They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase . They associate with spliceosome components and are required for mRNA splicing . .

AccessionsENST00000620016.2
P0C5Y9