H1-6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H1-6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H1-6 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0045910Biological processnegative regulation of DNA recombination
GO_0006334Biological processnucleosome assembly
GO_0030261Biological processchromosome condensation
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0030527Molecular functionstructural constituent of chromatin
GO_0031492Molecular functionnucleosomal DNA binding

IV. Literature review

[source]
Gene nameH1-6
Protein nameHistone cluster 1, H1t
Histone H1t (Testicular H1 histone)
SynonymsHIST1H1T
H1T
H1FT
DescriptionFUNCTION: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes . Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination . Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). .

AccessionsENST00000338379.6
A1L407
P22492