I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enteroendocrine cell | 4 studies | 43% ± 19% | |
| enterocyte | 3 studies | 19% ± 4% | |
| epithelial cell | 3 studies | 30% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enteroendocrine cell | 4 studies | 43% ± 19% | |
| enterocyte | 3 studies | 19% ± 4% | |
| epithelial cell | 3 studies | 30% ± 7% |
Insufficient scRNA-seq data for expression of GUCY2C at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 96% | 2025.65 | 927 / 966 | 87% | 45.80 | 460 / 527 |
| stomach | 73% | 13.05 | 261 / 359 | 78% | 38.66 | 223 / 286 |
| pancreas | 100% | 30.43 | 327 / 328 | 20% | 7.04 | 36 / 178 |
| esophagus | 69% | 32.91 | 993 / 1445 | 39% | 14.67 | 72 / 183 |
| uterus | 90% | 35.22 | 153 / 170 | 3% | 0.62 | 16 / 459 |
| breast | 91% | 26.35 | 419 / 459 | 1% | 0.07 | 13 / 1118 |
| kidney | 91% | 16.89 | 81 / 89 | 1% | 0.08 | 11 / 901 |
| adipose | 89% | 18.94 | 1069 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 88% | 16.80 | 577 / 653 | 0% | 0 | 0 / 605 |
| prostate | 87% | 22.25 | 212 / 245 | 1% | 0.05 | 5 / 502 |
| bladder | 62% | 19.86 | 13 / 21 | 25% | 12.54 | 124 / 504 |
| liver | 69% | 11.73 | 155 / 226 | 17% | 2.22 | 70 / 406 |
| heart | 85% | 23.01 | 734 / 861 | 0% | 0 | 0 / 0 |
| spleen | 81% | 15.66 | 196 / 241 | 0% | 0 | 0 / 0 |
| skin | 72% | 105.49 | 1306 / 1809 | 1% | 0.02 | 3 / 472 |
| lung | 59% | 8.56 | 342 / 578 | 13% | 3.15 | 147 / 1155 |
| peripheral blood | 70% | 21.26 | 653 / 929 | 0% | 0 | 0 / 0 |
| muscle | 61% | 8.92 | 487 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 59% | 10.25 | 785 / 1335 | 0% | 0 | 0 / 0 |
| brain | 53% | 9.87 | 1389 / 2642 | 0% | 0.00 | 1 / 705 |
| ovary | 34% | 4.38 | 62 / 180 | 0% | 0.01 | 1 / 430 |
| adrenal gland | 24% | 2.81 | 62 / 258 | 0% | 0.01 | 1 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 3.06 | 2 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007168 | Biological process | receptor guanylyl cyclase signaling pathway |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0006182 | Biological process | cGMP biosynthetic process |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005525 | Molecular function | GTP binding |
| GO_0001653 | Molecular function | peptide receptor activity |
| GO_0004016 | Molecular function | adenylate cyclase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0015643 | Molecular function | toxic substance binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004383 | Molecular function | guanylate cyclase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| Gene name | GUCY2C |
| Protein name | Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (hSTAR) (Intestinal guanylate cyclase) Alternative protein GUCY2C |
| Synonyms | STAR GUC2C |
| Description | FUNCTION: Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP . Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C . Also activated by the endogenous peptides guanylin and uroguanylin . . |
| Accessions | ENST00000261170.5 L0R6I0 P25092 |
