GTF2H4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GTF2H4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GTF2H4 at tissue level.

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0006366Biological processtranscription by RNA polymerase II
GO_0006281Biological processDNA repair
GO_0016607Cellular componentnuclear speck
GO_0000438Cellular componentcore TFIIH complex portion of holo TFIIH complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0005634Cellular componentnucleus
GO_0001671Molecular functionATPase activator activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGTF2H4
Protein nameGeneral transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)
General transcription factor IIH subunit 4
Synonyms
DescriptionFUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. .

FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. .

AccessionsENST00000259895.9 [Q92759-1]
A0A0G2JHJ2
ENST00000435498.5 [Q92759-1]
ENST00000423849.6
ENST00000438348.5 [Q92759-1]
ENST00000416161.2
ENST00000423881.5 [Q92759-1]
ENST00000456968.6 [Q92759-1]
ENST00000413314.6 [Q92759-1]
ENST00000376326.8 [Q92759-1]
ENST00000456195.2
ENST00000430576.2
ENST00000416773.5 [Q92759-1]
ENST00000400450.1 [Q92759-1]
ENST00000376316.5 [Q92759-1]
ENST00000454718.2
Q92759
ENST00000434226.6 [Q92759-1]
ENST00000440824.6 [Q92759-1]