GTF2H2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GTF2H2 at tissue level.

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0006366Biological processtranscription by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0009411Biological processresponse to UV
GO_0002031Biological processG protein-coupled receptor internalization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0000438Cellular componentcore TFIIH complex portion of holo TFIIH complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0005634Cellular componentnucleus
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameGTF2H2
Protein nameGeneral transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)
GTF2H2 family member C (General transcription factor IIH subunit 2)
General transcription factor IIH subunit 2
SynonymsGTF2H2C
GTF2H2C_2
BTF2P44
DescriptionFUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. .

AccessionsENST00000617228.4 [Q13888-1]
ENST00000518898.6
D6RAW1
ENST00000274400.10 [Q13888-1]
ENST00000628423.2 [Q13888-1]
ENST00000626970.1
ENST00000619997.4 [Q13888-1]
ENST00000612324.1
ENST00000511629.6
ENST00000612581.4 [Q13888-1]
R4GMS9
ENST00000446221.6
Q13888
ENST00000616846.4
R4GMV2
ENST00000425596.5
ENST00000514069.6
ENST00000521602.2
ENST00000330280.11 [Q13888-1]
ENST00000619880.4
ENST00000519783.5
ENST00000630101.2