GTF2H1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0006289Biological processnucleotide-excision repair
GO_0006366Biological processtranscription by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006281Biological processDNA repair
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0009755Biological processhormone-mediated signaling pathway
GO_0006360Biological processtranscription by RNA polymerase I
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameGTF2H1
Protein nameGeneral transcription factor IIH subunit 1
General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)
SynonymsBTF2
DescriptionFUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. .

AccessionsENST00000265963.9 [P32780-1]
ENST00000453096.6 [P32780-1]
ENST00000524753.4
ENST00000672845.1 [P32780-2]
ENST00000672827.1 [P32780-1]
F5H0Y9
ENST00000526630.2
ENST00000672527.1 [P32780-1]
ENST00000525831.5
E9PM51
E9PI26
E9PL58
P32780
ENST00000534641.5 [P32780-2]
ENST00000530496.6