GTDC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006400Biological processtRNA modification
GO_0006417Biological processregulation of translation
GO_0005634Cellular componentnucleus
GO_0005737Cellular componentcytoplasm
GO_0016438Molecular functiontRNA-queuosine(34) beta-mannosyltransferase activity

IV. Literature review

[source]
Gene nameGTDC1
Protein nameAlternative protein GTDC1
Glycosyltransferase-like domain-containing protein 1
tRNA-queuosine alpha-mannosyltransferase (QTMAN) (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1) (Mannosyltransferase-like protein Xa) (Mat-Xa)
SynonymsQTMAN
DescriptionFUNCTION: Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)) . Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34) . Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation . .

AccessionsENST00000344850.8 [Q4AE62-1]
F2Z2V8
ENST00000542155.5 [Q4AE62-1]
ENST00000415569.5
B8ZZ45
ENST00000409214.5 [Q4AE62-1]
ENST00000463875.6 [Q4AE62-6]
C9JIH3
ENST00000392869.6 [Q4AE62-1]
ENST00000618778.4 [Q4AE62-5]
ENST00000392871.6 [Q4AE62-4]
C9J2C5
Q4AE62
ENST00000392867.7 [Q4AE62-2]
ENST00000682281.1 [Q4AE62-1]
ENST00000417450.5
ENST00000437114.5
L0R871
ENST00000241391.9 [Q4AE62-4]
ENST00000409298.5