GSDMC report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GSDMC at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GSDMC at tissue level.

III. Associated gene sets

GO_0070269Biological processpyroptotic inflammatory response
GO_0042742Biological processdefense response to bacterium
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding

IV. Literature review

[source]
Gene nameGSDMC
Protein nameGasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)]
Gasdermin-C
SynonymsMLZE
DescriptionFUNCTION: [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. .; FUNCTION: [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis . Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals . After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids . Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . .

AccessionsENST00000646090.1
Q9BYG8
A0A2R8Y5J4
ENST00000619643.1
ENST00000642712.2
ENST00000276708.9