GSDMB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GSDMB at tissue level.

III. Associated gene sets

GO_0031640Biological processkilling of cells of another organism
GO_0070269Biological processpyroptotic inflammatory response
GO_0042742Biological processdefense response to bacterium
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding

IV. Literature review

[source]
Gene nameGSDMB
Protein nameGasdermin-B (Gasdermin-like protein) [Cleaved into: Gasdermin-B, N-terminal (GSDMB-NT) (p30); Gasdermin-B, C-terminal (GSDMB-CT) (p16)]
Gasdermin B (Gasdermin-like isoform GSDML3)
Gasdermin B
Gasdermin B (Gasdermin-like isoform GSDML2)
Gasdermin B (Gasdermin-like isoform GSDML4)
SynonymsPRO2521
PP4052
GSDML
DescriptionFUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death . This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis . Also acts as a regulator of epithelial cell repair independently of programmed cell death: translocates to the plasma membrane and promotes epithelial maintenance and repair by regulating PTK2/FAK-mediated phosphorylation of PDGFA . .; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells . Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form . After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . The different isoforms recognize and bind different phospholipids on membranes, promoting cell death of different target cells . .; FUNCTION: [Isoform 4]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and mediates pyroptosis . Following cleavage and activation by granzyme A (GZMA), the N-terminal part binds to membrane inner leaflet lipids, homooligomerizes within the human plasma membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Recognizes and binds membrane inner leaflet lipids of human cells, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid . Also binds sufatide, a component of the apical membrane of epithelial cells . .; FUNCTION: [Isoform 6]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and mediates pyroptosis of human cells . Following cleavage and activation by granzyme A (GZMA), the N-terminal part binds to membrane inner leaflet lipids, homooligomerizes within the human plasma membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . .; FUNCTION: [Isoform 1]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and specifically mediates cell death of Gram-negative bacteria in response to infection . Following cleavage and activation by granzyme A (GZMA), the N-terminal part recognizes and binds phospholipids found on Gram-negative bacterial membranes, such as lipid A and cariolipin, homooligomerizes within the bacterial membranes and forms pores, triggering pyroptosis followed by cell death . In contrast to isoform 4, does not bind to membrane inner leaflet lipids of host human cell, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate . .; FUNCTION: [Isoform 2]: Not able to trigger pyroptosis. .; FUNCTION: [Isoform 3]: Not able to trigger pyroptosis. .

AccessionsENST00000394175.6 [Q8TAX9-2]
B2CM71
ENST00000523371.5
ENST00000468820.1
B2CM72
ENST00000418519.6 [Q8TAX9-4]
ENST00000309481.11 [Q8TAX9-3]
ENST00000524039.5
ENST00000520542.5 [Q8TAX9-6]
ENST00000522564.5
J3QLF0
B2CM73
Q8TAX9
ENST00000394179.5 [Q8TAX9-3]
ENST00000360317.7 [Q8TAX9-4]