GRIN3B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRIN3B at tissue level.

III. Associated gene sets

GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0051924Biological processregulation of calcium ion transport
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0060078Biological processregulation of postsynaptic membrane potential
GO_0051205Biological processprotein insertion into membrane
GO_0070588Biological processcalcium ion transmembrane transport
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_0043025Cellular componentneuronal cell body
GO_0017146Cellular componentNMDA selective glutamate receptor complex
GO_0008066Molecular functionglutamate receptor activity
GO_1904315Molecular functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004972Molecular functionNMDA glutamate receptor activity
GO_0005261Molecular functionmonoatomic cation channel activity
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0016594Molecular functionglycine binding
GO_0099507Molecular functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameGRIN3B
Protein nameGlutamate receptor
Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B)
Synonyms
DescriptionFUNCTION: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

AccessionsQ5F0I5
O60391
ENST00000234389.3
Q5F0I4