Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 14 studies | 68% ± 18% | |
| GABAergic neuron | 11 studies | 49% ± 25% | |
| astrocyte | 8 studies | 32% ± 17% | |
| glutamatergic neuron | 7 studies | 35% ± 11% | |
| microglial cell | 5 studies | 30% ± 14% | |
| interneuron | 5 studies | 53% ± 29% | |
| endothelial cell | 4 studies | 30% ± 18% | |
| OFF-bipolar cell | 4 studies | 71% ± 28% | |
| retinal bipolar neuron | 3 studies | 26% ± 7% | |
| GABAergic interneuron | 3 studies | 53% ± 27% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 12 studies | 29% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 781.85 | 2631 / 2642 | 86% | 10.48 | 604 / 705 |
| prostate | 77% | 278.99 | 188 / 245 | 50% | 3.16 | 249 / 502 |
| adrenal gland | 37% | 398.11 | 95 / 258 | 45% | 13.40 | 104 / 230 |
| breast | 47% | 105.69 | 215 / 459 | 13% | 1.18 | 149 / 1118 |
| skin | 42% | 36.83 | 766 / 1809 | 3% | 0.25 | 14 / 472 |
| bladder | 33% | 69.90 | 7 / 21 | 3% | 0.17 | 17 / 504 |
| intestine | 33% | 32.91 | 315 / 966 | 2% | 0.07 | 12 / 527 |
| stomach | 22% | 25.64 | 78 / 359 | 2% | 0.60 | 6 / 286 |
| uterus | 10% | 12.65 | 17 / 170 | 7% | 0.36 | 32 / 459 |
| adipose | 16% | 16.30 | 189 / 1204 | 0% | 0 | 0 / 0 |
| lung | 8% | 4.97 | 47 / 578 | 5% | 0.30 | 62 / 1155 |
| kidney | 8% | 6.31 | 7 / 89 | 5% | 0.55 | 48 / 901 |
| ovary | 12% | 14.65 | 22 / 180 | 0% | 0.01 | 2 / 430 |
| esophagus | 10% | 9.18 | 139 / 1445 | 1% | 0.02 | 2 / 183 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.59 | 7 / 80 |
| thymus | 5% | 3.04 | 30 / 653 | 3% | 0.07 | 17 / 605 |
| pancreas | 1% | 0.65 | 3 / 328 | 2% | 0.14 | 4 / 178 |
| muscle | 3% | 1.94 | 24 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 2% | 2.42 | 32 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 2% | 1.45 | 5 / 241 | 0% | 0 | 0 / 0 |
| liver | 1% | 0.76 | 2 / 226 | 1% | 0.07 | 4 / 406 |
| heart | 1% | 0.71 | 6 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 0.46 | 6 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0035235 | Biological process | ionotropic glutamate receptor signaling pathway |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0007417 | Biological process | central nervous system development |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0007215 | Biological process | glutamate receptor signaling pathway |
| GO_0007399 | Biological process | nervous system development |
| GO_0035249 | Biological process | synaptic transmission, glutamatergic |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0032983 | Cellular component | kainate selective glutamate receptor complex |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004970 | Molecular function | glutamate-gated receptor activity |
| GO_0015277 | Molecular function | kainate selective glutamate receptor activity |
| GO_0022849 | Molecular function | glutamate-gated calcium ion channel activity |
| Gene name | GRIK1 |
| Protein name | Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5) Glutamate receptor GRIK1 protein (Glutamate receptor) |
| Synonyms | GLUR5 |
| Description | FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . |
| Accessions | H7BYG7 ENST00000399914.5 ENST00000389125.7 [P39086-2] E7EPY9 ENST00000389124.6 E7ENK3 A0A8D9PH76 Q9UNN1 ENST00000399907.6 [P39086-1] ENST00000399913.5 E9PD61 ENST00000399909.5 P39086 E7EPZ0 ENST00000327783.9 |
