I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 6 studies | 27% ± 9% | |
| ciliated cell | 4 studies | 20% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 6 studies | 27% ± 9% | |
| ciliated cell | 4 studies | 20% ± 4% |
Insufficient scRNA-seq data for expression of GRAMD2A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1467.77 | 576 / 578 | 73% | 8.57 | 847 / 1155 |
| thymus | 100% | 1658.86 | 651 / 653 | 60% | 3.80 | 363 / 605 |
| prostate | 93% | 366.06 | 227 / 245 | 63% | 3.20 | 315 / 502 |
| kidney | 99% | 532.45 | 88 / 89 | 50% | 2.38 | 453 / 901 |
| intestine | 64% | 234.06 | 621 / 966 | 69% | 4.30 | 361 / 527 |
| breast | 63% | 862.61 | 290 / 459 | 69% | 7.67 | 772 / 1118 |
| brain | 77% | 350.25 | 2043 / 2642 | 34% | 1.25 | 237 / 705 |
| esophagus | 42% | 86.45 | 603 / 1445 | 58% | 2.96 | 106 / 183 |
| ovary | 8% | 9.44 | 15 / 180 | 89% | 12.31 | 382 / 430 |
| stomach | 45% | 59.23 | 163 / 359 | 48% | 2.83 | 136 / 286 |
| skin | 72% | 259.18 | 1300 / 1809 | 6% | 0.25 | 29 / 472 |
| uterus | 15% | 92.06 | 25 / 170 | 59% | 3.52 | 272 / 459 |
| bladder | 29% | 29.38 | 6 / 21 | 41% | 4.10 | 206 / 504 |
| pancreas | 3% | 3.29 | 9 / 328 | 49% | 2.47 | 88 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 44% | 1.57 | 20 / 45 |
| blood vessel | 10% | 11.01 | 128 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 3% | 3.31 | 35 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 0.65 | 2 / 258 | 1% | 0.04 | 3 / 230 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.09 | 5 / 406 |
| heart | 1% | 1.44 | 9 / 861 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0.32 | 1 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.42 | 3 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.48 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0061817 | Biological process | endoplasmic reticulum-plasma membrane tethering |
| GO_2001256 | Biological process | regulation of store-operated calcium entry |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0044232 | Cellular component | organelle membrane contact site |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| Gene name | GRAMD2A |
| Protein name | GRAM domain-containing protein 2A GRAM domain containing 2A |
| Synonyms | GRAMD2 |
| Description | FUNCTION: Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). . |
| Accessions | H3BTA1 ENST00000570275.5 H3BTY3 ENST00000562288.1 ENST00000568594.5 ENST00000564129.5 ENST00000309731.12 H3BTF7 H3BUI8 Q8IUY3 |
