GRAMD1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071397Biological processcellular response to cholesterol
GO_0032366Biological processintracellular sterol transport
GO_0005886Cellular componentplasma membrane
GO_0140268Cellular componentendoplasmic reticulum-plasma membrane contact site
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015485Molecular functioncholesterol binding
GO_0005515Molecular functionprotein binding
GO_0120020Molecular functioncholesterol transfer activity

IV. Literature review

[source]
Gene nameGRAMD1C
Protein nameGRAM domain containing 1C
GRAM domain containing 1C, isoform CRA_d (cDNA FLJ40464 fis, clone TESTI2042264)
Protein Aster-C (GRAM domain-containing protein 1C)
GRAM domain containing 1C (cDNA FLJ57959)
SynonymsUNQ2543/PRO6095
hCG_18871
DescriptionFUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). .

AccessionsENST00000484714.2
ENST00000462838.5
ENST00000440446.2 [Q8IYS0-2]
C9J7B8
ENST00000472384.5
E9PHT3
ENST00000472026.5
C9K0V2
Q8IYS0
B3KUR5
ENST00000488680.1
F8WCA8
B4DF12
ENST00000358160.9 [Q8IYS0-1]