Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 12 studies | 42% ± 25% | |
astrocyte | 12 studies | 41% ± 19% | |
microglial cell | 10 studies | 31% ± 8% | |
oligodendrocyte precursor cell | 10 studies | 36% ± 15% | |
plasmacytoid dendritic cell | 9 studies | 22% ± 5% | |
retinal cone cell | 7 studies | 60% ± 25% | |
GABAergic neuron | 7 studies | 50% ± 23% | |
macrophage | 7 studies | 26% ± 7% | |
interneuron | 6 studies | 47% ± 24% | |
retinal ganglion cell | 6 studies | 45% ± 17% | |
retinal rod cell | 5 studies | 54% ± 22% | |
neuron | 4 studies | 28% ± 4% | |
endothelial cell | 4 studies | 29% ± 14% | |
granule cell | 4 studies | 54% ± 23% | |
cardiac muscle cell | 4 studies | 45% ± 22% | |
GABAergic interneuron | 3 studies | 31% ± 1% | |
Mueller cell | 3 studies | 25% ± 7% | |
retina horizontal cell | 3 studies | 24% ± 8% | |
rod bipolar cell | 3 studies | 27% ± 8% | |
retinal pigment epithelial cell | 3 studies | 40% ± 22% | |
alveolar macrophage | 3 studies | 26% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 35610.99 | 258 / 258 | 99% | 38.86 | 227 / 230 |
brain | 98% | 10683.23 | 2599 / 2642 | 98% | 16.29 | 690 / 705 |
ovary | 96% | 3136.36 | 172 / 180 | 57% | 2.96 | 244 / 430 |
thymus | 60% | 763.14 | 394 / 653 | 71% | 3.78 | 429 / 605 |
kidney | 82% | 1652.45 | 73 / 89 | 42% | 2.10 | 382 / 901 |
stomach | 74% | 2221.48 | 267 / 359 | 40% | 3.09 | 115 / 286 |
lymph node | 0% | 0 | 0 / 0 | 93% | 12.05 | 27 / 29 |
pancreas | 4% | 38.05 | 13 / 328 | 82% | 8.16 | 146 / 178 |
intestine | 21% | 676.78 | 201 / 966 | 31% | 2.77 | 163 / 527 |
lung | 23% | 226.82 | 131 / 578 | 29% | 2.46 | 330 / 1155 |
spleen | 43% | 400.29 | 104 / 241 | 0% | 0 | 0 / 0 |
esophagus | 1% | 12.04 | 13 / 1445 | 41% | 4.78 | 75 / 183 |
heart | 42% | 1094.85 | 359 / 861 | 0% | 0 | 0 / 0 |
skin | 8% | 89.74 | 142 / 1809 | 31% | 2.27 | 147 / 472 |
uterus | 3% | 26.57 | 5 / 170 | 32% | 2.89 | 145 / 459 |
liver | 1% | 11.79 | 3 / 226 | 32% | 2.82 | 128 / 406 |
peripheral blood | 22% | 306.49 | 205 / 929 | 0% | 0 | 0 / 0 |
muscle | 17% | 203.56 | 133 / 803 | 0% | 0 | 0 / 0 |
breast | 5% | 70.35 | 24 / 459 | 9% | 0.55 | 96 / 1118 |
eye | 0% | 0 | 0 / 0 | 11% | 0.93 | 9 / 80 |
bladder | 0% | 0 | 0 / 21 | 11% | 0.64 | 54 / 504 |
adipose | 6% | 79.37 | 72 / 1204 | 0% | 0 | 0 / 0 |
prostate | 4% | 33.54 | 10 / 245 | 0% | 0.01 | 2 / 502 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.05 | 1 / 45 |
blood vessel | 2% | 20.39 | 28 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042632 | Biological process | cholesterol homeostasis |
GO_0071397 | Biological process | cellular response to cholesterol |
GO_0032366 | Biological process | intracellular sterol transport |
GO_0140268 | Cellular component | endoplasmic reticulum-plasma membrane contact site |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0070300 | Molecular function | phosphatidic acid binding |
GO_0015485 | Molecular function | cholesterol binding |
GO_0001786 | Molecular function | phosphatidylserine binding |
GO_0120020 | Molecular function | cholesterol transfer activity |
Gene name | GRAMD1B |
Protein name | Protein Aster-B (GRAM domain-containing protein 1B) GRAM domain containing 1B GRAM domain containing 1B (HCG39893, isoform CRA_a) |
Synonyms | KIAA1201 hCG_39893 UNQ3032/PRO9834 |
Description | FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). . |
Accessions | ENST00000633087.1 ENST00000529432.5 [Q3KR37-2] E9PRD6 ENST00000534764.1 A0A1B0GWG7 ENST00000646146.1 ENST00000632815.1 A0A1B0GVV0 A0A1W2PQ30 A0A2R8Y5X2 A0A1B0GUD6 ENST00000633646.1 ENST00000640939.1 ENST00000529750.5 [Q3KR37-1] ENST00000450171.2 [Q3KR37-3] A0A0J9YY71 A0A024R3M2 ENST00000638086.1 A0A0J9YXF6 ENST00000638157.1 A0A0J9YXZ1 ENST00000456860.6 [Q3KR37-4] ENST00000635736.2 ENST00000533341.3 Q3KR37 |