GRAMD1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042632Biological processcholesterol homeostasis
GO_0071397Biological processcellular response to cholesterol
GO_0032366Biological processintracellular sterol transport
GO_0140268Cellular componentendoplasmic reticulum-plasma membrane contact site
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070300Molecular functionphosphatidic acid binding
GO_0015485Molecular functioncholesterol binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0120020Molecular functioncholesterol transfer activity

IV. Literature review

[source]
Gene nameGRAMD1B
Protein nameProtein Aster-B (GRAM domain-containing protein 1B)
GRAM domain containing 1B
GRAM domain containing 1B (HCG39893, isoform CRA_a)
SynonymsKIAA1201
hCG_39893
UNQ3032/PRO9834
DescriptionFUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). .

AccessionsENST00000633087.1
ENST00000529432.5 [Q3KR37-2]
E9PRD6
ENST00000534764.1
A0A1B0GWG7
ENST00000646146.1
ENST00000632815.1
A0A1B0GVV0
A0A1W2PQ30
A0A2R8Y5X2
A0A1B0GUD6
ENST00000633646.1
ENST00000640939.1
ENST00000529750.5 [Q3KR37-1]
ENST00000450171.2 [Q3KR37-3]
A0A0J9YY71
A0A024R3M2
ENST00000638086.1
A0A0J9YXF6
ENST00000638157.1
A0A0J9YXZ1
ENST00000456860.6 [Q3KR37-4]
ENST00000635736.2
ENST00000533341.3
Q3KR37