GPN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPN1 at tissue level.

III. Associated gene sets

GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGPN1
Protein nameGPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1)
GPN-loop GTPase (EC 3.6.5.-)
SynonymsMBDIN
RPAP4
HUSSY-23
XAB1
DescriptionFUNCTION: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) . May act at an RNAP assembly step prior to nuclear import . Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation . May be involved in nuclear localization of XPA . .

FUNCTION: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. .

AccessionsQ9HCN4
ENST00000424214.5 [Q9HCN4-2]
ENST00000610189.2 [Q9HCN4-1]
ENST00000616939.4 [Q9HCN4-5]
F8WD09
ENST00000264718.7 [Q9HCN4-5]
ENST00000436280.5
ENST00000407583.7 [Q9HCN4-4]
ENST00000503738.5 [Q9HCN4-3]
ENST00000515877.5 [Q9HCN4-2]
ENST00000458167.6 [Q9HCN4-3]