GPD1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000649Biological processregulation of sodium ion transmembrane transporter activity
GO_0090038Biological processnegative regulation of protein kinase C signaling
GO_0005975Biological processcarbohydrate metabolic process
GO_0086005Biological processventricular cardiac muscle cell action potential
GO_0002027Biological processregulation of heart rate
GO_0060373Biological processregulation of ventricular cardiac muscle cell membrane depolarization
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0046168Biological processglycerol-3-phosphate catabolic process
GO_0006116Biological processNADH oxidation
GO_0019674Biological processNAD metabolic process
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0051287Molecular functionNAD binding
GO_0047952Molecular functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0017080Molecular functionsodium channel regulator activity
GO_0141152Molecular functionglycerol-3-phosphate dehydrogenase (NAD+) activity

IV. Literature review

[source]
Gene nameGPD1L
Protein nameGlycerol-3-phosphate dehydrogenase 1 like
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8)
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8)
SynonymsKIAA0089
DescriptionFUNCTION: Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. .

AccessionsENST00000425459.5
ENST00000282541.10
Q8N335
C9JFA7
F8WC16
ENST00000428684.1
ENST00000429432.5
C9K0P5
C9JM46
ENST00000431009.1