Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 20% ± 4% | |
epithelial cell | 7 studies | 30% ± 10% | |
neuron | 4 studies | 24% ± 6% | |
retinal ganglion cell | 4 studies | 49% ± 27% | |
retinal cone cell | 4 studies | 37% ± 14% | |
GABAergic neuron | 4 studies | 38% ± 10% | |
hepatocyte | 4 studies | 46% ± 26% | |
ciliated cell | 3 studies | 28% ± 7% | |
glutamatergic neuron | 3 studies | 50% ± 13% | |
dendritic cell | 3 studies | 21% ± 2% | |
abnormal cell | 3 studies | 25% ± 7% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 5% | |
basal cell | 3 studies | 21% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 8024.45 | 258 / 258 | 100% | 139.55 | 230 / 230 |
bladder | 100% | 5323.05 | 21 / 21 | 100% | 138.09 | 504 / 504 |
liver | 100% | 12898.86 | 226 / 226 | 100% | 174.66 | 406 / 406 |
ovary | 100% | 3191.23 | 180 / 180 | 100% | 79.96 | 430 / 430 |
prostate | 100% | 5557.86 | 245 / 245 | 100% | 147.66 | 502 / 502 |
stomach | 100% | 4780.39 | 359 / 359 | 100% | 125.57 | 286 / 286 |
uterus | 100% | 3906.82 | 170 / 170 | 100% | 108.20 | 459 / 459 |
esophagus | 100% | 6069.79 | 1444 / 1445 | 100% | 138.63 | 183 / 183 |
intestine | 100% | 5022.69 | 966 / 966 | 100% | 140.25 | 526 / 527 |
kidney | 100% | 6659.43 | 89 / 89 | 100% | 117.38 | 899 / 901 |
thymus | 100% | 4489.53 | 652 / 653 | 100% | 91.75 | 603 / 605 |
skin | 100% | 4978.62 | 1807 / 1809 | 100% | 105.70 | 470 / 472 |
brain | 98% | 5765.69 | 2579 / 2642 | 100% | 87.59 | 705 / 705 |
lung | 98% | 2999.47 | 565 / 578 | 100% | 101.83 | 1152 / 1155 |
breast | 97% | 3405.59 | 443 / 459 | 99% | 122.70 | 1112 / 1118 |
pancreas | 91% | 1999.66 | 298 / 328 | 99% | 77.83 | 177 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 232.41 | 29 / 29 |
muscle | 100% | 23180.53 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3243.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 115.89 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 94.00 | 1 / 1 |
blood vessel | 99% | 3013.59 | 1320 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 101.75 | 79 / 80 |
heart | 98% | 18494.36 | 843 / 861 | 0% | 0 | 0 / 0 |
adipose | 95% | 2152.21 | 1141 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 41% | 2620.57 | 383 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006103 | Biological process | 2-oxoglutarate metabolic process |
GO_0097052 | Biological process | L-kynurenine metabolic process |
GO_0006107 | Biological process | oxaloacetate metabolic process |
GO_0045471 | Biological process | response to ethanol |
GO_0019470 | Biological process | 4-hydroxyproline catabolic process |
GO_0006533 | Biological process | aspartate catabolic process |
GO_0015908 | Biological process | fatty acid transport |
GO_0006536 | Biological process | glutamate metabolic process |
GO_0006532 | Biological process | aspartate biosynthetic process |
GO_0006531 | Biological process | aspartate metabolic process |
GO_0019551 | Biological process | glutamate catabolic process to 2-oxoglutarate |
GO_0019550 | Biological process | glutamate catabolic process to aspartate |
GO_0005886 | Cellular component | plasma membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0030170 | Molecular function | pyridoxal phosphate binding |
GO_0016212 | Molecular function | kynurenine-oxoglutarate transaminase activity |
GO_0003723 | Molecular function | RNA binding |
GO_0004069 | Molecular function | L-aspartate:2-oxoglutarate aminotransferase activity |
Gene name | GOT2 |
Protein name | Glutamic-oxaloacetic transaminase 2 Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) |
Synonyms | KYAT4 |
Description | FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. . |
Accessions | P00505 ENST00000434819.2 [P00505-2] H3BRE7 ENST00000568368.1 ENST00000245206.10 [P00505-1] |