Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney loop of Henle epithelial cell | 6 studies | 27% ± 8% | |
| glutamatergic neuron | 6 studies | 43% ± 21% | |
| epithelial cell | 6 studies | 30% ± 8% | |
| cardiac muscle cell | 6 studies | 39% ± 8% | |
| epithelial cell of proximal tubule | 5 studies | 20% ± 3% | |
| renal alpha-intercalated cell | 5 studies | 37% ± 6% | |
| retinal ganglion cell | 5 studies | 76% ± 26% | |
| retinal cone cell | 5 studies | 31% ± 13% | |
| hepatocyte | 5 studies | 48% ± 26% | |
| astrocyte | 5 studies | 24% ± 3% | |
| GABAergic neuron | 5 studies | 46% ± 15% | |
| oligodendrocyte | 5 studies | 18% ± 3% | |
| neuron | 4 studies | 26% ± 7% | |
| endothelial cell | 4 studies | 24% ± 3% | |
| amacrine cell | 4 studies | 39% ± 12% | |
| retinal rod cell | 4 studies | 21% ± 3% | |
| ciliated cell | 4 studies | 20% ± 1% | |
| interneuron | 4 studies | 36% ± 16% | |
| retinal bipolar neuron | 3 studies | 34% ± 11% | |
| retina horizontal cell | 3 studies | 33% ± 9% | |
| basal cell | 3 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 18271.08 | 226 / 226 | 100% | 310.57 | 406 / 406 |
| kidney | 100% | 7913.21 | 89 / 89 | 100% | 162.94 | 899 / 901 |
| adrenal gland | 96% | 3857.11 | 248 / 258 | 100% | 105.29 | 229 / 230 |
| esophagus | 95% | 2785.39 | 1370 / 1445 | 100% | 78.04 | 183 / 183 |
| brain | 94% | 8102.27 | 2494 / 2642 | 100% | 81.52 | 704 / 705 |
| intestine | 91% | 3128.67 | 880 / 966 | 100% | 86.22 | 526 / 527 |
| stomach | 91% | 4103.45 | 328 / 359 | 99% | 77.10 | 284 / 286 |
| thymus | 87% | 2286.31 | 569 / 653 | 100% | 71.89 | 603 / 605 |
| skin | 84% | 2240.36 | 1524 / 1809 | 99% | 66.42 | 469 / 472 |
| prostate | 80% | 1713.52 | 196 / 245 | 99% | 63.25 | 498 / 502 |
| bladder | 67% | 1270.10 | 14 / 21 | 99% | 69.31 | 497 / 504 |
| ovary | 57% | 1303.88 | 102 / 180 | 100% | 59.74 | 429 / 430 |
| lung | 50% | 1184.85 | 287 / 578 | 100% | 78.66 | 1151 / 1155 |
| breast | 49% | 891.27 | 223 / 459 | 99% | 68.70 | 1103 / 1118 |
| pancreas | 43% | 824.25 | 140 / 328 | 99% | 58.24 | 177 / 178 |
| uterus | 39% | 739.49 | 67 / 170 | 99% | 88.07 | 456 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 50.65 | 29 / 29 |
| muscle | 100% | 19114.25 | 803 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 108.29 | 45 / 45 |
| eye | 0% | 0 | 0 / 0 | 99% | 60.00 | 79 / 80 |
| heart | 97% | 24117.97 | 831 / 861 | 0% | 0 | 0 / 0 |
| spleen | 68% | 1301.15 | 165 / 241 | 0% | 0 | 0 / 0 |
| adipose | 31% | 580.11 | 375 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 24% | 451.67 | 324 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 20% | 785.77 | 184 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006103 | Biological process | 2-oxoglutarate metabolic process |
| GO_0055089 | Biological process | fatty acid homeostasis |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0006107 | Biological process | oxaloacetate metabolic process |
| GO_0006114 | Biological process | glycerol biosynthetic process |
| GO_0006533 | Biological process | aspartate catabolic process |
| GO_0006536 | Biological process | glutamate metabolic process |
| GO_0006532 | Biological process | aspartate biosynthetic process |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0006094 | Biological process | gluconeogenesis |
| GO_0006531 | Biological process | aspartate metabolic process |
| GO_0019551 | Biological process | glutamate catabolic process to 2-oxoglutarate |
| GO_0019550 | Biological process | glutamate catabolic process to aspartate |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0030170 | Molecular function | pyridoxal phosphate binding |
| GO_0004609 | Molecular function | phosphatidylserine decarboxylase activity |
| GO_0047801 | Molecular function | L-cysteine transaminase activity |
| GO_0004069 | Molecular function | L-aspartate:2-oxoglutarate aminotransferase activity |
| Gene name | GOT1 |
| Protein name | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) |
| Synonyms | |
| Description | FUNCTION: Biosynthesis of L-glutamate from L-aspartate or L-cysteine . Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway . . |
| Accessions | P17174 ENST00000370508.7 [P17174-1] |