GOT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006103Biological process2-oxoglutarate metabolic process
GO_0055089Biological processfatty acid homeostasis
GO_0032869Biological processcellular response to insulin stimulus
GO_0007219Biological processNotch signaling pathway
GO_0006107Biological processoxaloacetate metabolic process
GO_0006114Biological processglycerol biosynthetic process
GO_0006533Biological processaspartate catabolic process
GO_0006536Biological processglutamate metabolic process
GO_0006532Biological processaspartate biosynthetic process
GO_0051384Biological processresponse to glucocorticoid
GO_0006094Biological processgluconeogenesis
GO_0006531Biological processaspartate metabolic process
GO_0019551Biological processglutamate catabolic process to 2-oxoglutarate
GO_0019550Biological processglutamate catabolic process to aspartate
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0004609Molecular functionphosphatidylserine decarboxylase activity
GO_0047801Molecular functionL-cysteine transaminase activity
GO_0004069Molecular functionL-aspartate:2-oxoglutarate aminotransferase activity

IV. Literature review

[source]
Gene nameGOT1
Protein nameAspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)
Synonyms
DescriptionFUNCTION: Biosynthesis of L-glutamate from L-aspartate or L-cysteine . Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway . .

AccessionsP17174
ENST00000370508.7 [P17174-1]