GOLGA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090166Biological processGolgi disassembly
GO_0008356Biological processasymmetric cell division
GO_0007020Biological processmicrotubule nucleation
GO_0007098Biological processcentrosome cycle
GO_0090307Biological processmitotic spindle assembly
GO_0007030Biological processGolgi organization
GO_0051225Biological processspindle assembly
GO_0060050Biological processpositive regulation of protein glycosylation
GO_0010507Biological processnegative regulation of autophagy
GO_0090306Biological processmeiotic spindle assembly
GO_0015031Biological processprotein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0032091Biological processnegative regulation of protein binding
GO_0090161Biological processGolgi ribbon formation
GO_0006486Biological processprotein glycosylation
GO_0051289Biological processprotein homotetramerization
GO_0005801Cellular componentcis-Golgi network
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0000137Cellular componentGolgi cis cisterna
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0032580Cellular componentGolgi cisterna membrane
GO_0019905Molecular functionsyntaxin binding
GO_0061676Molecular functionimportin-alpha family protein binding
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGOLGA2
Protein nameGolgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)
Golgi matrix protein GM130
Golgin subfamily A member 2
Golgin A2
Synonyms
DescriptionFUNCTION: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) . Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization . Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle . Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization . Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins . .

AccessionsENST00000611957.5
B7ZC06
A0A8I5KYU9
ENST00000686884.1
ENST00000693185.1
ENST00000421699
A0A8I5KT73
ENST00000686291.1
ENST00000610329.5
A0A8J9BZL8
A0A1W2PQY5
ENST00000490628.3
ENST00000450617.8
ENST00000692923.1
A0A8I5KZ68
ENST00000693047.1
A0A8I5QL14
A0A8I5KQL3
Q08379
A0A8I5KRU0
ENST00000691841.1
ENST00000693180.1
A0A8I5KNZ1
R4GND7
ENST00000693736.1
H0Y7B8
ENST00000458730.3
ENST00000421699.8 [Q08379-1]
A0A8I5KZ34
ENST00000685382.1
A0A6Q8KRG2
A0A8I5KUW5
A0A8I5KYB0
ENST00000639983.2
Q5PXD5
A0A8I5QJQ7
ENST00000685900.1
ENST00000687179.1
A0A087WYC0