GNPDA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006046Biological processN-acetylglucosamine catabolic process
GO_0006048Biological processUDP-N-acetylglucosamine biosynthetic process
GO_0005975Biological processcarbohydrate metabolic process
GO_0006043Biological processglucosamine catabolic process
GO_0019262Biological processN-acetylneuraminate catabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016853Molecular functionisomerase activity
GO_0004342Molecular functionglucosamine-6-phosphate deaminase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGNPDA2
Protein nameGlucosamine-6-phosphate isomerase 2 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 2) (GNPDA 2) (GlcN6P deaminase 2) (Glucosamine-6-phosphate isomerase SB52)
Glucosamine-6-phosphate deaminase 2
SynonymsGNP2
DescriptionFUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. .

AccessionsENST00000295448.8 [Q8TDQ7-1]
ENST00000507917.5 [Q8TDQ7-5]
ENST00000509756.1 [Q8TDQ7-3]
V9GYK3
V9GYW0
ENST00000507534.5 [Q8TDQ7-4]
ENST00000609092.5
Q8TDQ7
ENST00000608855.1