Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 17 studies | 25% ± 11% | |
myeloid cell | 5 studies | 30% ± 15% | |
epithelial cell of proximal tubule | 4 studies | 17% ± 1% | |
epithelial cell | 4 studies | 29% ± 11% | |
classical monocyte | 3 studies | 26% ± 8% | |
conventional dendritic cell | 3 studies | 20% ± 3% | |
basal cell | 3 studies | 26% ± 10% | |
abnormal cell | 3 studies | 18% ± 2% | |
GABAergic neuron | 3 studies | 27% ± 4% | |
glutamatergic neuron | 3 studies | 35% ± 5% | |
dendritic cell | 3 studies | 25% ± 3% | |
non-classical monocyte | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 2968.43 | 21 / 21 | 100% | 56.76 | 504 / 504 |
esophagus | 100% | 1615.09 | 1445 / 1445 | 100% | 35.34 | 183 / 183 |
ovary | 100% | 2755.24 | 180 / 180 | 100% | 44.96 | 430 / 430 |
thymus | 100% | 2500.04 | 653 / 653 | 100% | 70.87 | 605 / 605 |
skin | 100% | 2231.64 | 1808 / 1809 | 100% | 75.32 | 472 / 472 |
breast | 100% | 1882.72 | 459 / 459 | 100% | 51.73 | 1117 / 1118 |
prostate | 100% | 2225.16 | 245 / 245 | 100% | 41.44 | 501 / 502 |
uterus | 100% | 2975.35 | 170 / 170 | 100% | 51.98 | 458 / 459 |
kidney | 100% | 3564.61 | 89 / 89 | 100% | 55.26 | 899 / 901 |
brain | 100% | 1940.09 | 2636 / 2642 | 100% | 57.27 | 705 / 705 |
lung | 100% | 1915.07 | 576 / 578 | 100% | 45.25 | 1154 / 1155 |
intestine | 100% | 2033.87 | 966 / 966 | 99% | 52.18 | 523 / 527 |
stomach | 99% | 1261.47 | 356 / 359 | 100% | 48.89 | 286 / 286 |
adrenal gland | 100% | 4093.58 | 258 / 258 | 98% | 49.20 | 226 / 230 |
pancreas | 95% | 712.39 | 312 / 328 | 99% | 38.64 | 176 / 178 |
liver | 99% | 810.68 | 223 / 226 | 85% | 21.28 | 345 / 406 |
adipose | 100% | 2090.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1644.47 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 79.65 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 39.56 | 29 / 29 |
muscle | 100% | 1658.03 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2755.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 42.29 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 24.15 | 1 / 1 |
heart | 96% | 1090.04 | 823 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 1249.77 | 876 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006046 | Biological process | N-acetylglucosamine catabolic process |
GO_0006048 | Biological process | UDP-N-acetylglucosamine biosynthetic process |
GO_0005975 | Biological process | carbohydrate metabolic process |
GO_0006091 | Biological process | generation of precursor metabolites and energy |
GO_0007338 | Biological process | single fertilization |
GO_0006043 | Biological process | glucosamine catabolic process |
GO_0019262 | Biological process | N-acetylneuraminate catabolic process |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0016853 | Molecular function | isomerase activity |
GO_0004342 | Molecular function | glucosamine-6-phosphate deaminase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | GNPDA1 |
Protein name | Glucosamine-6-phosphate isomerase (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase) Glucosamine-6-phosphate deaminase 1 Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin) Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (Oscillin) |
Synonyms | KIAA0060 HLN GNPI |
Description | FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis . Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling . Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). . |
Accessions | P46926 D6R9P4 D6RFF8 ENST00000510194.5 D6RFK5 ENST00000504424.1 ENST00000503794.5 [P46926-1] D6RB13 ENST00000508177.5 [P46926-1] ENST00000500692.6 [P46926-1] D6RAY7 ENST00000513454.5 ENST00000311337.11 [P46926-1] ENST00000505689.5 ENST00000504139.5 D6R917 ENST00000503229.5 |