GNPDA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006046Biological processN-acetylglucosamine catabolic process
GO_0006048Biological processUDP-N-acetylglucosamine biosynthetic process
GO_0005975Biological processcarbohydrate metabolic process
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0007338Biological processsingle fertilization
GO_0006043Biological processglucosamine catabolic process
GO_0019262Biological processN-acetylneuraminate catabolic process
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016853Molecular functionisomerase activity
GO_0004342Molecular functionglucosamine-6-phosphate deaminase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGNPDA1
Protein nameGlucosamine-6-phosphate isomerase (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase)
Glucosamine-6-phosphate deaminase 1
Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin)
Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (Oscillin)
SynonymsKIAA0060
HLN
GNPI
DescriptionFUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis . Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling . Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). .

AccessionsP46926
D6R9P4
D6RFF8
ENST00000510194.5
D6RFK5
ENST00000504424.1
ENST00000503794.5 [P46926-1]
D6RB13
ENST00000508177.5 [P46926-1]
ENST00000500692.6 [P46926-1]
D6RAY7
ENST00000513454.5
ENST00000311337.11 [P46926-1]
ENST00000505689.5
ENST00000504139.5
D6R917
ENST00000503229.5