GNE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046835Biological processcarbohydrate phosphorylation
GO_0006047Biological processUDP-N-acetylglucosamine metabolic process
GO_0046380Biological processN-acetylneuraminate biosynthetic process
GO_0006045Biological processN-acetylglucosamine biosynthetic process
GO_0005829Cellular componentcytosol
GO_0008761Molecular functionUDP-N-acetylglucosamine 2-epimerase activity
GO_0004553Molecular functionhydrolase activity, hydrolyzing O-glycosyl compounds
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0009384Molecular functionN-acylmannosamine kinase activity

IV. Literature review

[source]
Gene nameGNE
Protein nameUDP-N-acetylglucosamine-2-epimerase / N-acetylmannosamine kinase
Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)]
SynonymsIBM2
GLCNE
DescriptionFUNCTION: Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation . Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition . .

AccessionsA0A7I2SU25
ENST00000447283.6 [Q9Y223-4]
ENST00000543356.7
Q6QNY6
Q6QNY5
ENST00000642385.2 [Q9Y223-1]
ENST00000396594.8 [Q9Y223-2]
ENST00000539208.5 [Q9Y223-5]
Q9Y223
Q6QNY7