GLDC | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	8 studies	26% ± 10%	Explore
astrocyte	7 studies	26% ± 9%	Explore
hepatocyte	5 studies	49% ± 20%	Explore
endothelial cell	3 studies	24% ± 9%	Explore
interneuron	3 studies	30% ± 8%	Explore
retinal pigment epithelial cell	3 studies	30% ± 5%	Explore
renal principal cell	3 studies	22% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GLDC at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	858.81	2584 / 2642	98%	25.30	694 / 705
liver	100%	8638.66	226 / 226	87%	23.00	353 / 406
kidney	100%	3623.84	89 / 89	68%	14.09	611 / 901
thymus	78%	796.83	509 / 653	12%	2.14	71 / 605
ovary	2%	9.73	3 / 180	74%	15.54	317 / 430
skin	38%	304.38	680 / 1809	34%	4.07	159 / 472
bladder	33%	196.05	7 / 21	27%	4.33	137 / 504
breast	26%	105.26	120 / 459	19%	2.98	210 / 1118
esophagus	26%	176.83	372 / 1445	18%	2.83	33 / 183
lymph node	0%	0	0 / 0	34%	3.03	10 / 29
lung	19%	39.55	111 / 578	15%	1.79	171 / 1155
spleen	34%	123.39	81 / 241	0%	0	0 / 0
uterus	2%	7.41	4 / 170	30%	5.14	138 / 459
prostate	7%	17.30	17 / 245	16%	1.75	79 / 502
peripheral blood	22%	1106.81	204 / 929	0%	0	0 / 0
intestine	12%	32.96	116 / 966	8%	0.99	43 / 527
muscle	19%	40.20	154 / 803	0%	0	0 / 0
stomach	3%	4.92	9 / 359	16%	2.12	47 / 286
tonsil	0%	0	0 / 0	18%	3.51	8 / 45
blood vessel	6%	11.79	77 / 1335	0%	0	0 / 0
pancreas	0%	0	0 / 328	5%	1.09	9 / 178
adrenal gland	2%	8.22	6 / 258	0%	0.02	1 / 230
adipose	2%	6.38	29 / 1204	0%	0	0 / 0
heart	0%	0.23	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0036255	Biological process	response to methylamine
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_1903442	Biological process	response to lipoic acid
GO_0006546	Biological process	glycine catabolic process
GO_0019464	Biological process	glycine decarboxylation via glycine cleavage system
GO_0005960	Cellular component	glycine cleavage complex
GO_0005654	Cellular component	nucleoplasm
GO_0005886	Cellular component	plasma membrane
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0016594	Molecular function	glycine binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0070280	Molecular function	pyridoxal binding
GO_0016829	Molecular function	lyase activity
GO_0030170	Molecular function	pyridoxal phosphate binding
GO_0004375	Molecular function	glycine dehydrogenase (decarboxylating) activity
GO_0009055	Molecular function	electron transfer activity

Gene name	GLDC
Protein name	Glycine decarboxylase Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) glycine dehydrogenase (aminomethyl-transferring) (EC 1.4.4.2)
Synonyms	GCSP
Description	FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). .
Accessions	ENST00000638654.1 ENST00000640208.1 P23378 ENST00000639639.1 A0A1W2PPH6 ENST00000639318.1 ENST00000639020.1 A0A1W2PP74 A0A1W2PPK8 A0A1W2PPD7 ENST00000638661.1 ENST00000321612.8 A0A1W2PPB1 A0A1W2PPE1 A0A1W2PPG0 A0A1W2PQV3 ENST00000638274.1 A0A1W2PQU6 ENST00000639840.1 ENST00000463305.1

GLDC report