GK2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GK2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GK2 at tissue level.

III. Associated gene sets

GO_0006071Biological processglycerol metabolic process
GO_0016310Biological processphosphorylation
GO_0007283Biological processspermatogenesis
GO_0030317Biological processflagellated sperm motility
GO_0006641Biological processtriglyceride metabolic process
GO_0019563Biological processglycerol catabolic process
GO_0120317Biological processsperm mitochondrial sheath assembly
GO_0046167Biological processglycerol-3-phosphate biosynthetic process
GO_0005741Cellular componentmitochondrial outer membrane
GO_0097225Cellular componentsperm midpiece
GO_0070062Cellular componentextracellular exosome
GO_0097226Cellular componentsperm mitochondrial sheath
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding
GO_0004370Molecular functionglycerol kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameGK2
Protein nameGlycerol kinase 2 (GK 2) (Glycerokinase 2) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 2) (Glycerol kinase, testis specific 2)
SynonymsGKTA
GKP2
DescriptionFUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria . .

AccessionsQ14410
ENST00000358842.5