GJB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GJB2 at tissue level.

III. Associated gene sets

GO_0032355Biological processresponse to estradiol
GO_0007605Biological processsensory perception of sound
GO_0010644Biological processcell communication by electrical coupling
GO_0002931Biological processresponse to ischemia
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0046697Biological processdecidualization
GO_0055085Biological processtransmembrane transport
GO_1905867Biological processepididymis development
GO_0048839Biological processinner ear development
GO_0007267Biological processcell-cell signaling
GO_0034599Biological processcellular response to oxidative stress
GO_1990349Biological processgap junction-mediated intercellular transport
GO_0071377Biological processcellular response to glucagon stimulus
GO_0032526Biological processresponse to retinoic acid
GO_0044752Biological processresponse to human chorionic gonadotropin
GO_0016264Biological processgap junction assembly
GO_0032570Biological processresponse to progesterone
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005922Cellular componentconnexin complex
GO_0097449Cellular componentastrocyte projection
GO_0016328Cellular componentlateral plasma membrane
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005921Cellular componentgap junction
GO_0044297Cellular componentcell body
GO_0042802Molecular functionidentical protein binding
GO_0005243Molecular functiongap junction channel activity
GO_1903763Molecular functiongap junction channel activity involved in cell communication by electrical coupling
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGJB2
Protein nameConnexin 26
Truncated gap junction protein beta 2
Gap junction beta-2 protein (Connexin-26) (Cx26)
Gap junction protein
SynonymshCG_18943
CX26
CXNE
DescriptionFUNCTION: Structural component of gap junctions . Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane . Small molecules and ions diffuse from one cell to a neighboring cell via the central pore . .

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

AccessionsA0A2R4SEG2
T1W1N3
T1W120
P29033
A8DU55
W8FX79
V5Q007
ENST00000382844.2
H9U1J4
ENST00000382848.5