GINS4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GINS4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GINS4 at tissue level.

III. Associated gene sets

GO_0000727Biological processdouble-strand break repair via break-induced replication
GO_0001833Biological processinner cell mass cell proliferation
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0000811Cellular componentGINS complex
GO_0071162Cellular componentCMG complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGINS4
Protein nameDNA replication complex GINS protein SLD5
GINS complex subunit 4
DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]
SynonymsSLD5
DescriptionFUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks . GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . .

FUNCTION: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. .

AccessionsENST00000520710.5 [Q9BRT9-2]
ENST00000518671.5 [Q9BRT9-1]
Q9BRT9
ENST00000523277.6
ENST00000276533.4 [Q9BRT9-1]
E5RH56
E5RFF9
ENST00000520354.5