GGA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006622Biological processprotein targeting to lysosome
GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0006886Biological processintracellular protein transport
GO_0031648Biological processprotein destabilization
GO_0034394Biological processprotein localization to cell surface
GO_0006893Biological processGolgi to plasma membrane transport
GO_0030163Biological processprotein catabolic process
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_1905167Biological processpositive regulation of lysosomal protein catabolic process
GO_0031647Biological processregulation of protein stability
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0010008Cellular componentendosome membrane
GO_0043130Molecular functionubiquitin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0031267Molecular functionsmall GTPase binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0140318Molecular functionprotein transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGGA3
Protein nameADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Golgi associated, gamma adaptin ear containing, ARF binding protein 3 (cDNA FLJ59841, highly similar to ADP-ribosylation factor-binding protein GGA3)
Golgi associated, gamma adaptin ear containing, ARF binding protein 3
SynonymsKIAA0154
DescriptionFUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels . Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation . Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination . Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). .

AccessionsB7Z1E9
ENST00000577435.5
ENST00000583282.5
ENST00000649398.1 [Q9NZ52-1]
ENST00000584550.1
J3KSG3
J3KTR5
ENST00000538886.5 [Q9NZ52-2]
G3V1K5
J3QRP3
ENST00000580799.2
ENST00000582376.1
ENST00000582486.5
ENST00000580646.5
ENST00000578773.1
ENST00000584243.5
ENST00000578348.5 [Q9NZ52-3]
ENST00000621217.4
ENST00000537686.6 [Q9NZ52-1]
A0A087WYN2
J3KSS7
J3QRK7
J3KS27
ENST00000579743.2
ENST00000582717.5 [Q9NZ52-4]
J3QRS8
ENST00000621870.4
Q9NZ52
J3QS87