GEMIN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GEMIN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GEMIN4 at tissue level.

III. Associated gene sets

GO_0006364Biological processrRNA processing
GO_0000387Biological processspliceosomal snRNP assembly
GO_0015030Cellular componentCajal body
GO_0005730Cellular componentnucleolus
GO_0097504Cellular componentGemini of coiled bodies
GO_0034719Cellular componentSMN-Sm protein complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016604Cellular componentnuclear body
GO_0030532Cellular componentsmall nuclear ribonucleoprotein complex
GO_0032797Cellular componentSMN complex
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGEMIN4
Protein nameGem nuclear organelle associated protein 4
Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97)
Gem (Nuclear organelle) associated protein 4
Synonyms
DescriptionFUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. .

AccessionsENST00000319004.6
P57678
ENST00000437269.1
ENST00000570364.5
I3L1J7
ENST00000576778.1
I3L4M4
ENST00000574958.1
I3L4A4
Q8WUM5
ENST00000573482.5
E7EN12
ENST00000576383.1
I3L2C7
I3L399