GDPD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070291Biological processN-acylethanolamine metabolic process
GO_0046475Biological processglycerophospholipid catabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004622Molecular functionlysophospholipase activity
GO_0046872Molecular functionmetal ion binding
GO_0008081Molecular functionphosphoric diester hydrolase activity

IV. Literature review

[source]
Gene nameGDPD1
Protein nameGlycerophosphodiester phosphodiesterase domain containing 1
Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)
SynonymsGDE4
DescriptionFUNCTION: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines . Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) . May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE) . In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine . Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity). .

AccessionsENST00000579076.1
ENST00000579020.5
J3QQN7
J3QRR6
ENST00000581276.5 [Q8N9F7-2]
J3KTA9
Q8N9F7
ENST00000578026.5
ENST00000284116.9 [Q8N9F7-1]
ENST00000581140.5 [Q8N9F7-3]