GCN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140469Biological processGCN2-mediated signaling
GO_0160127Biological processprotein-RNA covalent cross-linking repair
GO_0072344Biological processrescue of stalled ribosome
GO_0034198Biological processcellular response to amino acid starvation
GO_0006417Biological processregulation of translation
GO_0022626Cellular componentcytosolic ribosome
GO_0005829Cellular componentcytosol
GO_0005840Cellular componentribosome
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0045296Molecular functioncadherin binding
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0019887Molecular functionprotein kinase regulator activity
GO_0170011Molecular functionstalled ribosome sensor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameGCN1
Protein nameAlternative protein GCN1L1
Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
SynonymsKIAA0219
GCN1L1
DescriptionFUNCTION: Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes . Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation . In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein . GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). .

AccessionsL8EAJ9
ENST00000300648.7
Q92616