GCKR | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	3 studies	62% ± 20%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GCKR at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	8784.69	226 / 226	97%	40.11	394 / 406
pancreas	79%	160.87	260 / 328	79%	5.80	141 / 178
adrenal gland	100%	918.01	258 / 258	26%	0.73	59 / 230
stomach	88%	484.27	317 / 359	28%	0.91	79 / 286
brain	76%	54.14	2016 / 2642	37%	0.65	258 / 705
ovary	99%	790.64	178 / 180	3%	0.05	13 / 430
prostate	90%	71.77	220 / 245	6%	0.12	32 / 502
spleen	95%	224.49	229 / 241	0%	0	0 / 0
adipose	91%	90.57	1091 / 1204	0%	0	0 / 0
esophagus	54%	73.73	784 / 1445	32%	1.54	58 / 183
breast	83%	82.41	382 / 459	1%	0.03	9 / 1118
blood vessel	75%	78.43	1003 / 1335	0%	0	0 / 0
kidney	56%	41.39	50 / 89	18%	0.88	162 / 901
lung	48%	25.27	280 / 578	16%	0.67	190 / 1155
bladder	52%	26.81	11 / 21	12%	0.68	62 / 504
thymus	38%	16.76	245 / 653	15%	0.24	91 / 605
uterus	45%	28.56	77 / 170	6%	0.17	28 / 459
intestine	30%	14.93	289 / 966	15%	0.85	81 / 527
heart	32%	21.54	274 / 861	0%	0	0 / 0
skin	30%	12.30	543 / 1809	1%	0.03	7 / 472
peripheral blood	19%	11.07	178 / 929	0%	0	0 / 0
muscle	19%	9.05	151 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046415	Biological process	urate metabolic process
GO_0070328	Biological process	triglyceride homeostasis
GO_0009749	Biological process	response to glucose
GO_1901135	Biological process	carbohydrate derivative metabolic process
GO_0009750	Biological process	response to fructose
GO_0006606	Biological process	protein import into nucleus
GO_0033132	Biological process	negative regulation of glucokinase activity
GO_0042593	Biological process	glucose homeostasis
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0019899	Molecular function	enzyme binding
GO_0004857	Molecular function	enzyme inhibitor activity
GO_0141089	Molecular function	glucose sensor activity
GO_0030246	Molecular function	carbohydrate binding
GO_0019210	Molecular function	kinase inhibitor activity
GO_0070095	Molecular function	fructose-6-phosphate binding
GO_0005515	Molecular function	protein binding

Gene name	GCKR
Protein name	Glucokinase regulatory protein (GKRP) (Glucokinase regulator) Glucokinase regulator Glucokinase (Hexokinase 4) regulator (Glucokinase regulator)
Synonyms	hCG_21226
Description	FUNCTION: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme . Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal . The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity . .
Accessions	A0A0C4DFN2 ENST00000411584.1 ENST00000264717.7 Q14397 H7C4D3 ENST00000453813.1 H7C1B4

GCKR report