GCK report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GCK at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GCK at tissue level.

III. Associated gene sets

GO_0006739Biological processNADP metabolic process
GO_0046835Biological processcarbohydrate phosphorylation
GO_0050796Biological processregulation of insulin secretion
GO_0032869Biological processcellular response to insulin stimulus
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0009749Biological processresponse to glucose
GO_0006096Biological processglycolytic process
GO_0006007Biological processglucose catabolic process
GO_0043266Biological processregulation of potassium ion transport
GO_0006110Biological processregulation of glycolytic process
GO_0001678Biological processintracellular glucose homeostasis
GO_0032024Biological processpositive regulation of insulin secretion
GO_0045725Biological processpositive regulation of glycogen biosynthetic process
GO_0070509Biological processcalcium ion import
GO_0061621Biological processcanonical glycolysis
GO_0044320Biological processcellular response to leptin stimulus
GO_0051156Biological processglucose 6-phosphate metabolic process
GO_0006006Biological processglucose metabolic process
GO_0042593Biological processglucose homeostasis
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0141089Molecular functionglucose sensor activity
GO_0019158Molecular functionmannokinase activity
GO_0005524Molecular functionATP binding
GO_0008865Molecular functionfructokinase activity
GO_0005536Molecular functionD-glucose binding
GO_0005515Molecular functionprotein binding
GO_0004340Molecular functionglucokinase activity

IV. Literature review

[source]
Gene nameGCK
Protein namePhosphotransferase (EC 2.7.1.-)
Glucokinase
Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D)
SynonymshCG_1745191
tcag7.801
DescriptionFUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) . Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues . Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate . .

AccessionsM4Q009
M4PT45
ENST00000671824.1
A7LFL1
ENST00000395796.8
M4PPE6
M4PS76
A0A8C8PZE6
P35557
ENST00000345378.7 [P35557-2]
M4PPI4
ENST00000673284.1
ENST00000336642.9
Q53Y25
M4Q000
ENST00000616242.5
ENST00000437084.1
H7BXV0
M4Q005
A0A5F9ZGW4
A0A5F9ZHE0
M4PS83
A0A8C8KJG0
L0HBA3
M4PPI9
C9JQD1
M4PS72
ENST00000403799.8 [P35557-1]
M4PPE1