Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 15 studies | 36% ± 21% | |
| astrocyte | 13 studies | 26% ± 8% | |
| oligodendrocyte | 13 studies | 35% ± 14% | |
| epithelial cell of proximal tubule | 7 studies | 65% ± 18% | |
| oligodendrocyte precursor cell | 7 studies | 37% ± 14% | |
| epithelial cell | 5 studies | 43% ± 21% | |
| hepatocyte | 5 studies | 75% ± 20% | |
| microglial cell | 4 studies | 31% ± 8% | |
| acinar cell | 4 studies | 65% ± 19% | |
| dendritic cell | 3 studies | 30% ± 14% | |
| endothelial cell | 3 studies | 22% ± 4% | |
| enterocyte | 3 studies | 25% ± 5% | |
| leukocyte | 3 studies | 19% ± 3% | |
| pancreatic ductal cell | 3 studies | 39% ± 15% | |
| glial cell | 3 studies | 25% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 49885.34 | 226 / 226 | 97% | 261.79 | 392 / 406 |
| brain | 100% | 10912.20 | 2641 / 2642 | 95% | 93.43 | 671 / 705 |
| kidney | 100% | 48622.07 | 89 / 89 | 87% | 121.93 | 784 / 901 |
| pancreas | 100% | 93520.74 | 328 / 328 | 83% | 60.06 | 148 / 178 |
| stomach | 87% | 2999.67 | 313 / 359 | 48% | 23.80 | 136 / 286 |
| bladder | 86% | 1841.05 | 18 / 21 | 28% | 9.32 | 139 / 504 |
| thymus | 71% | 1712.86 | 461 / 653 | 41% | 9.90 | 250 / 605 |
| ovary | 97% | 9345.87 | 175 / 180 | 10% | 2.19 | 44 / 430 |
| intestine | 73% | 1957.36 | 702 / 966 | 28% | 10.03 | 146 / 527 |
| esophagus | 45% | 892.33 | 657 / 1445 | 54% | 23.68 | 98 / 183 |
| skin | 70% | 3934.25 | 1274 / 1809 | 25% | 7.45 | 117 / 472 |
| adrenal gland | 65% | 1478.19 | 167 / 258 | 7% | 2.35 | 17 / 230 |
| breast | 30% | 630.99 | 138 / 459 | 40% | 9.33 | 448 / 1118 |
| blood vessel | 62% | 1844.67 | 834 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 62% | 1947.90 | 500 / 803 | 0% | 0 | 0 / 0 |
| spleen | 59% | 1239.41 | 143 / 241 | 0% | 0 | 0 / 0 |
| uterus | 17% | 305.65 | 29 / 170 | 37% | 11.77 | 171 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 11.68 | 15 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 8.70 | 19 / 45 |
| heart | 41% | 927.16 | 354 / 861 | 0% | 0 | 0 / 0 |
| prostate | 35% | 754.97 | 85 / 245 | 2% | 0.23 | 8 / 502 |
| lung | 1% | 19.95 | 6 / 578 | 29% | 7.33 | 338 / 1155 |
| adipose | 30% | 686.07 | 364 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 20% | 2058.10 | 187 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0014889 | Biological process | muscle atrophy |
| GO_0006600 | Biological process | creatine metabolic process |
| GO_0007611 | Biological process | learning or memory |
| GO_0006601 | Biological process | creatine biosynthetic process |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0005758 | Cellular component | mitochondrial intermembrane space |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0015068 | Molecular function | glycine amidinotransferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0015067 | Molecular function | amidinotransferase activity |
| Gene name | GATM |
| Protein name | Glycine amidinotransferase Glycine amidinotransferase (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase) Alternative protein GATM |
| Synonyms | AGAT |
| Description | FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives . Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable). . FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. . FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. . FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. . FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. . FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. . FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. . |
| Accessions | ENST00000674905.1 P50440 H0YMX4 ENST00000675158.1 ENST00000559885.1 ENST00000675701.1 A0A6Q8PF48 A0A6Q8PGA2 ENST00000396659.8 [P50440-1] L8E7A2 A0A6Q8PHC6 ENST00000558118.1 H0YKW9 ENST00000558537.5 H0YLC6 ENST00000676090.1 ENST00000558163.1 ENST00000561148.5 ENST00000558336.5 [P50440-3] A0A6Q8PFC6 H0YL75 ENST00000675323.1 [P50440-3] H0YN43 |