GAS2L2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GAS2L2 at tissue level.

III. Associated gene sets

GO_0031110Biological processregulation of microtubule polymerization or depolymerization
GO_0060296Biological processregulation of cilium beat frequency involved in ciliary motility
GO_1904825Biological processprotein localization to microtubule plus-end
GO_0051764Biological processactin crosslink formation
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_0001578Biological processmicrotubule bundle formation
GO_0035371Cellular componentmicrotubule plus-end
GO_0001725Cellular componentstress fiber
GO_0036064Cellular componentciliary basal body
GO_0005886Cellular componentplasma membrane
GO_0005884Cellular componentactin filament
GO_0005737Cellular componentcytoplasm
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0051015Molecular functionactin filament binding
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameGAS2L2
Protein nameGAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2)
SynonymsGAR17
DescriptionFUNCTION: Involved in the cross-linking of microtubules and microfilaments . Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers . Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway . .

AccessionsQ8NHY3
ENST00000604641.6 [Q8NHY3-1]