GALNT4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GALNT4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GALNT4 at tissue level.

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0018243Biological processprotein O-linked glycosylation via threonine
GO_0006493Biological processprotein O-linked glycosylation
GO_0018242Biological processprotein O-linked glycosylation via serine
GO_0000139Cellular componentGolgi membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030145Molecular functionmanganese ion binding
GO_0004653Molecular functionpolypeptide N-acetylgalactosaminyltransferase activity
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGALNT4
Protein namePolypeptide N-acetylgalactosaminyltransferase 4 (EC 2.4.1.41) (Polypeptide GalNAc transferase 4) (GalNAc-T4) (pp-GaNTase 4) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4)
Alternative protein GALNT4
Synonyms
DescriptionFUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG. .

AccessionsENST00000529983.3 [Q8N4A0-1]
L8EA58
Q8N4A0