FXYD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000649Biological processregulation of sodium ion transmembrane transporter activity
GO_0006813Biological processpotassium ion transport
GO_0006821Biological processchloride transport
GO_0006936Biological processmuscle contraction
GO_1903278Biological processpositive regulation of sodium ion export across plasma membrane
GO_1902476Biological processchloride transmembrane transport
GO_0006814Biological processsodium ion transport
GO_0010734Biological processnegative regulation of protein glutathionylation
GO_0086036Biological processregulation of cardiac muscle cell membrane potential
GO_0008016Biological processregulation of heart contraction
GO_0016324Cellular componentapical plasma membrane
GO_0005890Cellular componentsodium:potassium-exchanging ATPase complex
GO_0005886Cellular componentplasma membrane
GO_0014704Cellular componentintercalated disc
GO_0042383Cellular componentsarcolemma
GO_0030315Cellular componentT-tubule
GO_0005901Cellular componentcaveola
GO_0044325Molecular functiontransmembrane transporter binding
GO_0017080Molecular functionsodium channel regulator activity
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameFXYD1
Protein namePhospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1)
FXYD domain-containing ion transport regulator
SynonymsPLM
DescriptionFUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. .

AccessionsENST00000351325.9
K7EQG4
ENST00000612146.4
ENST00000588715.5
ENST00000589121.1
ENST00000588081.5
ENST00000455515.6
C7E9P5
ENST00000589209.5
ENST00000588607.5
O00168