FUT9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009312Biological processoligosaccharide biosynthetic process
GO_1903037Biological processregulation of leukocyte cell-cell adhesion
GO_0010976Biological processpositive regulation of neuron projection development
GO_0036445Biological processneuronal stem cell division
GO_0106402Biological processLewis x epitope biosynthetic process
GO_0036065Biological processfucosylation
GO_0005975Biological processcarbohydrate metabolic process
GO_0000271Biological processpolysaccharide biosynthetic process
GO_0042355Biological processL-fucose catabolic process
GO_1903236Biological processregulation of leukocyte tethering or rolling
GO_0036071Biological processN-glycan fucosylation
GO_0030182Biological processneuron differentiation
GO_0006493Biological processprotein O-linked glycosylation
GO_0006487Biological processprotein N-linked glycosylation
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0005794Cellular componentGolgi apparatus
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0008417Molecular functionfucosyltransferase activity
GO_0017083Molecular function4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
GO_0046920Molecular functionalpha-(1->3)-fucosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFUT9
Protein nameAlternative protein FUT9 (cDNA FLJ52603)
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase)
Fucosyltransferase (EC 2.4.1.-)
SynonymshCG_16703
DescriptionFUNCTION: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation . Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE . Can also modify milk oligosaccharides, in particular type 2 tetrasaccharide LNnT . .

AccessionsQ9Y231
ENST00000302103.6
B4DEW1
Q5Q0U2