Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 5 studies | 24% ± 9% | |
| respiratory goblet cell | 4 studies | 24% ± 6% | |
| squamous epithelial cell | 4 studies | 52% ± 17% | |
| epithelial cell | 4 studies | 29% ± 9% | |
| secretory cell | 3 studies | 18% ± 1% |
Insufficient scRNA-seq data for expression of FUT3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 98% | 388.95 | 321 / 328 | 90% | 67.37 | 160 / 178 |
| intestine | 61% | 3058.37 | 585 / 966 | 94% | 112.02 | 496 / 527 |
| stomach | 55% | 320.21 | 198 / 359 | 82% | 75.71 | 235 / 286 |
| lung | 61% | 449.90 | 351 / 578 | 75% | 29.57 | 866 / 1155 |
| esophagus | 44% | 3610.90 | 636 / 1445 | 70% | 46.04 | 128 / 183 |
| bladder | 29% | 88.52 | 6 / 21 | 78% | 54.25 | 391 / 504 |
| kidney | 85% | 428.29 | 76 / 89 | 12% | 3.67 | 106 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 39.67 | 32 / 45 |
| uterus | 8% | 86.44 | 14 / 170 | 62% | 31.48 | 284 / 459 |
| skin | 54% | 94.78 | 974 / 1809 | 1% | 0.23 | 7 / 472 |
| breast | 32% | 82.21 | 146 / 459 | 20% | 4.90 | 227 / 1118 |
| liver | 41% | 55.27 | 93 / 226 | 7% | 2.85 | 28 / 406 |
| prostate | 42% | 146.12 | 102 / 245 | 0% | 0.02 | 1 / 502 |
| ovary | 1% | 0.59 | 1 / 180 | 12% | 1.78 | 50 / 430 |
| thymus | 0% | 0.51 | 3 / 653 | 3% | 0.49 | 19 / 605 |
| adipose | 2% | 3.90 | 27 / 1204 | 0% | 0 | 0 / 0 |
| brain | 2% | 2.00 | 43 / 2642 | 0% | 0.01 | 1 / 705 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.32 | 1 / 80 |
| blood vessel | 1% | 0.83 | 8 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 1.57 | 4 / 803 | 0% | 0 | 0 / 0 |
| spleen | 0% | 1.28 | 1 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 1.47 | 1 / 258 | 0% | 0 | 0 / 230 |
| peripheral blood | 0% | 3.21 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0009312 | Biological process | oligosaccharide biosynthetic process |
| GO_0036065 | Biological process | fucosylation |
| GO_0043413 | Biological process | macromolecule glycosylation |
| GO_0006672 | Biological process | ceramide metabolic process |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0006493 | Biological process | protein O-linked glycosylation |
| GO_0006487 | Biological process | protein N-linked glycosylation |
| GO_0009988 | Biological process | cell-cell recognition |
| GO_0009311 | Biological process | oligosaccharide metabolic process |
| GO_0022409 | Biological process | positive regulation of cell-cell adhesion |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0032580 | Cellular component | Golgi cisterna membrane |
| GO_0017060 | Molecular function | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity |
| GO_0008417 | Molecular function | fucosyltransferase activity |
| GO_0017083 | Molecular function | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity |
| GO_0046920 | Molecular function | alpha-(1->3)-fucosyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FUT3 |
| Protein name | Fucosyltransferase 3 Galactoside 3(4)-L-fucosyltransferase Fucosyltransferase 3 (Lewis blood group) 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III) Truncated fucosyltransferase 3 Fucosyltransferase (EC 2.4.1.-) |
| Synonyms | FT3B LE hCG_1645372 |
| Description | FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors . Through its catalytic activity, participates in the synthesis of antigens of the Lewis blood group system, i.e. Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens . Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sLe(a) expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration . Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin . Prefers type 1 chain over type 2 acceptors . Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred . Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme . . |
| Accessions | ENST00000458379.7 A0A866W340 A0A7G4RBI5 ENST00000585715.1 B5B9M4 ENST00000587048.1 A0A7M1IM91 A0A7G4RBK5 B3GVC1 ENST00000709635.1 A0A7G4RBI3 P21217 A0A7M1IM29 A0A866W0T5 A0A866W2F7 A0A7G4RBH2 ENST00000709634.1 A0A866W0V3 A0A7M1IMC7 K7ENT3 K7EQ20 K7ES24 B3W6H0 A0A9E8S311 A0A9E8S0H5 A0A7S6PT87 A0A7G4RBK1 A0A7M1IMC0 A0A7M1IM08 A0A7M1IM40 ENST00000303225.12 A0A866W2E4 A0A866VVC5 ENST00000709636.1 A8K737 A0A7M1IM18 ENST00000589714.1 ENST00000589918.5 A0A7G4RBJ2 ENST00000589620.6 ENST00000709637.1 A0A866W2F4 A0A7M1IME8 A0A7M1ILZ8 Q9P1W6 A0A866W2F3 |
