FUT1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FUT1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FUT1 at tissue level.

III. Associated gene sets

GO_0009312Biological processoligosaccharide biosynthetic process
GO_0036065Biological processfucosylation
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0005975Biological processcarbohydrate metabolic process
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0042355Biological processL-fucose catabolic process
GO_0021772Biological processolfactory bulb development
GO_1904906Biological processpositive regulation of endothelial cell-matrix adhesion via fibronectin
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0030155Biological processregulation of cell adhesion
GO_0001936Biological processregulation of endothelial cell proliferation
GO_0006486Biological processprotein glycosylation
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0008417Molecular functionfucosyltransferase activity
GO_0008107Molecular functiongalactoside 2-alpha-L-fucosyltransferase activity
GO_0031127Molecular functionalpha-(1,2)-fucosyltransferase activity

IV. Literature review

[source]
Gene nameFUT1
Protein nameTruncated alpha-2 fucosyltransferase 1
Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)
L-Fucosyltransferase (EC 2.4.1.-)
Truncated alpha(1,2)fucosyltransferase
SynonymsH
hCG_16221
HSC
DescriptionFUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens . H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis . Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity). .

AccessionsA0A0A0R222
A0A977TNB7
A0A3G2WIG3
Q4JGW8
A0A076G425
A0A386QWH3
A7XM32
Q6IZA2
A0A0A0QYD1
E3UTT6
A0A7T0BS97
F1D990
Q8WXB6
A0A7T6AP85
C7F6W7
A0A385KNS6
A0A7S8F8B8
A0A385KNS4
A0A165G1H9
A0A2U9N2U7
B3GVB9
U5NK91
J9XSG7
A0A097IQZ3
A0A386QWH6
A0A385KNT8
A0A7G7XP25
C0L7J0
A0A385KNT2
F5BH05
T1WH77
A0A3G1I9E6
ENST00000645652.2
A0A3G1NJS2
P19526
A0A7L9R2Q2
I7C6Y9
A7XM28
A7XM36
Q8IVN2
A0A386QWJ3